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GI Microbiota and Regulation of the Immune System


GI Microbiota and Regulation of the Immune System



von: Gary B. Huffnagle, Mairi Noverr

149,79 €

Verlag: Springer
Format: PDF
Veröffentl.: 07.03.2009
ISBN/EAN: 9780387095509
Sprache: englisch
Anzahl Seiten: 149

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Beschreibungen

Overview of Gut Immunology.- The Commensal Microbiology of the Gastrointestinal Tract.- Overview of the Gastrointestinal Microbiota.- Effects of Microbiota on GI Health: Gnotobiotic Research.- Positive Interactions with the Microbiota: Probiotics.- Negative Interactions with the Microbiota: IBD.- Diet, Immunity and Functional Foods.- Host-Microbe Communication within the GI Tract.- Host-Microbe Symbiosis: The Squid-Vibrio Association—A Naturally Occurring, Experimental Model of Animal/Bacterial Partnerships.- The “Microflora Hypothesis” of Allergic Disease.- The Damage-Response Framework of Microbial Pathogenesis and Infectious Diseases.
<P><STRONG>Gary B. Huffnagle</STRONG>, PhD, is a Professor of Internal Medicine (Pulmonary</P>
<P>Diseases) and Microbiology and Immunology at the University of Michigan Medical</P>
<P>School. He holds a BS in microbiology from Pennsylvania State University and a</P>
<P>PhD in immunology from the University of Texas Southwestern Medical School.</P>
<P>In addition to conducting research, he teaches undergraduate and graduate classes</P>
<P>in eukaryotic microbiology, microbial symbiosis and experimental immunology</P>
<P>at the University of Michigan. Dr. Huffnagle’s research focuses on the regulation</P>
<P>of pulmonary immunity to infectious agents and allergens. In the past 5 years, his</P>
<P>attention has turned to the role of the indigenous microbiota in immune system</P>
<P>functioning, as well as the role of probiotics in animal and human health. He has</P>
<P>been awarded research grants from the National Heart, Lung and Blood Institute</P>
<P>(NHL BI), National Institute of Allergy and Infectious Diseases (NIAID), the Francis</P>
<P>Families Foundation and the Burroughs-Wellcome Fund. Dr. Huffnagle serves or</P>
<P>has served on editorial boards for the American Society for Microbiology (ASM)</P>
<P>and the American Association of Immunologists (AAI), as well as on advisory and</P>
<P>review panels for the National Institutes of Health (NIH).</P>
<P><STRONG>Mairi C. Nove rr</STRONG>, PhD, is an Assistant Professor of Immunology and</P>
<P>Microbiology at Wayne State University Medical School. She earned a BA in biology</P>
<P>from Kalamazoo College in 1996 and a PhD in microbiology and immunology</P>
<P>from the University of Michigan in 2002. Dr. Noverr’s current research focuses on</P>
<P>investigating mechanisms of immunomodulation by the opportunistic yeast Candida</P>
<P>albicans during host-pathogen interactions and how interactions with other members</P>
<P>of the microbiota influence these interactions. Her laboratory is investigating</P>
<P>signaling compounds called oxylipins that are produced by both Candida and the</P>
<P>host, which can influence the microbiology of the fungus and the activity of host</P>
<P>immune system cells. Projects in the laboratory include molecular characterization</P>
<P>of the fungal oxylipin biosynthetic pathways and determining the effects of oxylipins</P>
<P>during Candida pathogenesis, in modulating host immune cell function, and</P>
<P>during fungal-bacterial interactions. She has been awarded research funding from</P>
<P>the Francis Families Foundation.</P>

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