Details

Retroviruses and Insights into Cancer


Retroviruses and Insights into Cancer



von: Jaquelin Dudley

190,39 €

Verlag: Springer
Format: PDF
Veröffentl.: 22.10.2010
ISBN/EAN: 9780387095813
Sprache: englisch
Anzahl Seiten: 363

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Beschreibungen

This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.
This book contains a series of review articles that focus on retroviral models of human and animal cancers. The reviews summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.
This book will contain a series of review articles that focus on retroviral models of human and animal cancers. Each article will be written by an expert in the field of retrovirology. The reviews will summarize current work on a particular retrovirus, with particular emphasis on the relevance of this research to human disease.

Table of Contents:
Chapter 1: Mouse mammary tumor virus
Chapter 2: Jaagsiekte sheep retrovirus
Chapter 3: Avian leukosis virus
Chapter 4: Abelson murine leukemia virus
Chapter 5: Human T-cell leukemia virus
Chapter 6: Feline leukemia virus
Chapter 7: Murine leukemia virus
Chapter 8: Spleen focus-forming virus
Chapter 9: Koala retrovirus
Chapter 10: Human immunodeficiency virus
Retroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.
Provides current research in a specific field where most publications are at least 10 years old
Editor is an established figure in the MMTV field
Will stay relevant for at least 4 years

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